Diabetes, obesity & metabolism , 19 (9), 12421251
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This narrative review is an attempt to elaborate and consolidate our current understanding of the molecular mechanisms of SARS-CoV-2 infection, the detrimental effect(s) of this infectious process on human metabolism, consequential symptomatic clinical manifestations, and damage to multiple organ systems
Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)
Going back to the STEP-UP trial with semaglutide it was seen in about 20% of patients in that trial as well on the 7.2mg dose